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pClinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemia and decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4 and 5.1/ppThe use of ACE inhibitors is not recommended during the first trimester of pregnancysee section 4.4The use of ACE inhibitors is contra-indicated during the second and third trimester of pregnancysee sections 4.3 and 4.4/ppThis medication may make you more sensitive to the sunLimit your time in the sunAvoid tanning booths and sunlampsUse sunscreen and wear protective clothing when outdoorsTell your doctor right away if you get sunburned or have skin blisters/redness./ppTreatment with a thiazide diuretic may impair glucose toleranceThis phenomenon appeared to be more likely to occur during the first weeks of combination treatment and in patients with renal impairmentOther antidiabetic drugs including insulin requirements in diabetic patients may be increaseddecreasedor unchanged./p

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