During the monotherapy phase of the double-blind, placebo-controlled trials of 18 months duration, 13 of 227 patients who received lamictal 100 to 400 mg day , 16 of 190 patients who received placebo, and 23 of 166 patients who received lithium discontinued therapy because of an adverse experience.
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pWomen and Other Hormonal Contraceptive Preparations or Hormone Replacement Therapy./ppWhile atazanavir/ritonavir does reduce the lamotrigine plasma concentrationno adjustments to the recommended dose-escalation guidelines for LAMICTAL should be necessary solely based on the use of atazanavir/ritonavirDose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMICTAL based on concomitant AED or other concomitant medicationssee Tables 12and 5In patients already taking maintenance doses of LAMICTAL and not taking glucuronidation inducersthe dose of LAMICTAL may need to be increased if atazanavir/ritonavir is addedor decreased if atazanavir/ritonavir is discontinuedsee CLINICAL PHARMACOLOGY/ppLAMICTAL is contraindicated in patients who have demonstrated hypersensitivitye.grashangioedemaacute urticariaextensive pruritusmucosal ulcerationto the drug or its ingredientssee BOXED WARNINGWARNINGS AND PRECAUTIONS/ppTable 11Adverse Reactions in PooledPlacebo-Controlled Adjunctive Trials in Pediatric Patients With Epilepsy a./p
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