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pElevations of ALT or ASTless than three times ULNmay occur in up to 15of patients treated with NSAIDs including celecoxib./ppThis content has not been reviewed within the past year and may not represent WebMD’s most up-to-date information./ppIn patients with JRA who are known or suspected to be poor CYP2C9 metabolizersconsider using alternative treatmentssee Use in Specific populationsand CLINICAL PHARMACOLOGY/ppIn controlled clinical trialselevated BUN occurred more frequently in patients receiving CELEBREX compared with patients on placeboThis laboratory abnormality was also seen in patients who received comparator NSAIDs in these studiesThe clinical significance of this abnormality has not been established./p

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