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pAlthough th was nstatistically signiicant dinc btwn ACTOS and placbth th-ya incidnc a ist vnt within this composit, th was nincas in motality in total macovascula vnts with ACTOS. Th numb ist occuncs and total individual vnts contibuting tth pimay composit ndpoint is shown in Tabl 9./ppACTOS is a thiazolidindion that dpnds on th psnc insulin its mchanism action. ACTOS dcass insulin sistanc in th piphy and in th liv sulting in incasd insulin-dpndnt glucos disposal and dcasd hpatic glucos output. Pioglitazon is not an insulin sctagogu. Pioglitazon is an agonist poxisom poliato-activatd cpto-gamma (PPA?). PPA cptos a ound in tissus impotant insulin action such as adipos tissu, skltal muscl, and liv. Activation PPA? nucla cptos modulats th tansciption a numb insulin sponsiv gns involvd in th contol glucos and lipid mtabolism./ppACTOS xts its antihypglycmic ct only in th psnc ndognous insulin. ACTOS should not b usd ttat typ 1 diabts diabtic ktoacidosis, as it would not b ctiv in ths sttings./ppAdjunct tdit and xcis in typ 2 diabts, as monothapy in combination with mtomin, insulin, a sulonylua. Limitations us: not tating typ 1 diabts diabtic ktoacidosis./ppPioglitazon is a diabts dug (thiazolidindion-typ, alscalld glitazons) usd along with a pop dit and xcis pogam tcontol high blood suga in patints with typ 2 diabts. It woks by hlping tstyou body’s pop spons tinsulin, thby lowing you blood suga./p

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