Young children have more total body water 80 to 90 of body weight than adults 55 to 60 of body weight 3 , so water-soluble drugs, such as indinavir, will have a larger apparent volume of distribution in children than in adults table 1 .
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is is important to know that indinavir is not an actual cure for hiv or aids.
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aprepitant, when administered as a 3-day oral regimen 125 mg 80 mg 80 mg , is a moderate cyp3a4 inhibitor and inducer and may additionally increase plasma concentrations of indinavir.
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coadministration of telithromycin with other drugs metabolized by cyp3a4, such as indinavir, may result in increased plasma concentrations of the other drugs and could increase or prolong both the therapeutic and adverse effects.
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a safe and effective dose has not been established when used with indinavir.
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eplerenone severe coadministration of indinavir and eplerenone is contraindicated.
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