Bupropion is used as a smoking cessation aid.
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an inter-trial comparison between normal subjects and subjects with end-stage renal failure demonstrated that the parent drug c max and auc values were comparable in the 2 groups, whereas the hydroxybupropion and threohydrobupropion metabolites had a 2.
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coadministration of bupropion with digoxin may decrease plasma digoxin levels.
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the elimination of bupropion and or the major metabolites of bupropion may be reduced by impaired renal function see precautions renal impairment .
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a better perspective on the serious adverse events associated with the use of bupropion is provided in the warnings and precautions sections.
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